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KMID : 0613820120220050569
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Journal of Life Science
2012 Volume.22 No. 5 p.569 ~ p.574
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The Effects of Exercise on Neurotrophins, Hepatocyte Growth Factor (HGF), and Oxidative Stress in Obese Children
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Woo Jin-Hee
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Abstract
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This study was conducted to investigate the effect of exercise on oxidative stress, nerve growth, and hepatocyte growth factors in obese children. After 12 weeks of aerobic exercise training, the aforementioned parameters before and after the training were compared. As a result, the nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) were shown to be lower in the OT than in the NT before and after the training, respectively ($p$ 수식 이미지p <0.05). The NGF was shown to have increased in both groups after the training (p <0.05). The hepatocyte growth factor (HGF) was shown to be higher in the OT than in the NT before the training (p <0.05), with no difference found afterwards. The malondialdehyde (MDA), ox-LDL, and 8-OHdG (Oxo-2'-deoxyguanosine) were shown to be higher in the OT than in the NT (p <0.05). For ox-LDL, a difference was found between before and after the training (p <0.05). The results of this study showed that obesity induced oxidative stress and caused the abnormalities of nerve and HGF secretion in obese children, and that the 12 weeks of aerobic exercise increased NGF levels, thereby promoting the development of neurogenesis in children.
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KEYWORD
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Exercise training, neurotrophins, hepatocyte growth factor, oxidative stress, obese children
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